Performers are listed alphabetically by first name.
- U. Utah Phillips
- U.S. Royalty
- U2
- UFO
- Ugly Kids Club
- UK
- Ultramagnetic MC's
- Ultravox
- Ume
- Umphrey's Mcgee
- Uncle Floyd
- Uncle Joe’s Big Ol’ Driver
- Uncle Lucius
- Uncle Mountain
- Uncle Tom's Committee
- Underground System
- Undesirable People
- Undlin & Wolfe
- UNI
- Unicycle Loves You
- Union Specific
- Union Suit Characters
- Unity
- Universal Sigh
- University of New Orleans Jazz Band
- Unknown
- Unknown Mortal Orchestra
- Unnatural Helpers
- Until The Ribbon Breaks
- Up The Chain
- Upstate
- Upstate Rubdown
- Uquine
- Urge Overkill
- Us, Today
- USA for Africa
- Utopia
- Utsav Lal